Scientific articles

Dr. Guillermo Antiñolo, a leading expert in maternal-fetal medicine and genetics, has made significant contributions to research in obstetrics and fetal medicine. Below is a list of key scientific articles that reflect the breadth and depth of his work, highlighting his impact on improving perinatal outcomes and managing fetal complications.

Intrapartum Ex-Utero Treatment (EXIT): Indications and Outcomes in Cervical and Oropharyngeal Masses in Fetuses

The EXIT procedure allows securing the baby’s breathing before birth in cases of neck and throat masses. A study reviewed five cases between 2008 and 2019, achieving successful results in all, with healthy babies and no complications. The characteristics of the mass and the amount of amniotic fluid are key to the success of the procedure.

Maternal Effects of Oral Digoxin Treatment in Fetal Tachyarrhythmia

This study evaluated maternal complications resulting from digoxin treatment for fetal tachyarrhythmia. In a review of ten cases treated over ten years, 30% of women experienced mild digestive symptoms, all related to high levels of digoxin in the blood. Adjusting the dose resolved the symptoms within 48 hours, showing that digoxin is safe with proper monitoring.

Maternal and Neonatal Outcomes After Intrapartum Ex-Utero Treatment for Congenital Diaphragmatic Hernia

The EXIT procedure improves the fetal-neonatal transition in fetuses with moderate congenital diaphragmatic hernia. In a review of 14 cases between 2007 and 2022, a neonatal survival rate of 85.7% was observed without pulmonary complications and with optimal physical and neurocognitive development. Maternal complications were minimal, demonstrating that EXIT is a safe and effective option for these cases.

Maternal and Obstetric Outcomes of Intrapartum Ex-Utero Treatment (EXIT)

The EXIT procedure is used to manage fetal conditions and ensure neonatal breathing while maintaining fetoplacental circulation. In a review of 34 cases between 2007 and 2022, minor maternal complications were observed in only 2.94% of cases without major complications. The results were comparable to elective cesarean deliveries, demonstrating that EXIT is a safe procedure with proper management.

Prenatal Diagnosis of VACTERL Association Following SARS-CoV-2 Infection in the First Trimester

We present the case of a pregnant woman who, after an early SARS-CoV-2 infection, was prenatally diagnosed with VACTERL association. The infection occurred in the fifth week of gestation, and the diagnosis was made by second-trimester ultrasound. This case highlights the need for further studies to determine the possible causal relationship between SARS-CoV-2 infection and congenital anomalies.

Mode of Delivery, Perinatal Outcomes, and Neurodevelopment in Monochorionic Diamniotic Twins

This study evaluated the impact of the mode of delivery on uncomplicated monochorionic diamniotic twins born between 32 and 37.6 weeks of gestation. Seventy-two cases were analyzed and compared between planned vaginal deliveries and planned cesarean sections. The results showed that planned vaginal delivery is safe and has a high success rate without increasing perinatal morbidity compared to cesarean sections. Neurocognitive development at two years was similar in both groups.

Perinatal Palliative Care: From Fetal to Neonatal Life

Perinatal palliative care focuses on improving the quality of life for neonatal patients with life-limiting fetal conditions without intending to prolong life. They directly involve parents from the diagnosis of the fetal disease. Advances in fetal medicine have improved prenatal diagnosis, facilitating informed decisions about birth interventions. This comprehensive approach prioritizes the well-being of the neonate and social support for the family.

Neurodevelopmental Outcomes at Two Years After Fetoscopic Laser Therapy for Twin-to-Twin Transfusion Syndrome

This study evaluated the impact of fetoscopic laser therapy on the neurocognitive development of monochorionic diamniotic twins with twin-to-twin transfusion syndrome (TTTS) compared to uncomplicated twins. In a review of 176 children, neurodevelopmental outcomes at two years were similar between both groups, highlighting the importance of long-term follow-up for these patients.

Impact of Pregnancy Planning on Obstetric and Perinatal Outcomes in Women with Pregestational Diabetes

This study evaluated how pregnancy planning improves glycemic control and affects pregnancy outcomes in women with pregestational diabetes. Among 425 women, those who planned their pregnancy showed lower HbA1c levels throughout pregnancy. Although improved glycemic control slightly reduced elevated fetal weight, no significant effects were observed on other obstetric or perinatal outcomes.

Long-term Neurodevelopmental Outcomes After Selective Fetoscopic Laser Therapy for Stage I Twin-to-Twin Transfusion Syndrome

This study evaluated the neurocognitive development at two years of fetuses who received selective fetoscopic laser therapy for stage I twin-to-twin transfusion syndrome (TTTS), comparing them to advanced TTTS and uncomplicated monochorionic diamniotic twins. Of the 156 children studied, 92.9% of stage I TTTS cases showed normal neurocognitive development comparable to uncomplicated twins. The results suggest that laser therapy for stage I TTTS is safe and effective in the long term.

Giant Right Atrium Aneurysm: Prenatal Diagnosis and Outcome of a Rare Congenital Anomaly

This study presents the case of a giant right atrium aneurysm diagnosed prenatally, a rare congenital anomaly. Early diagnosis allowed for adequate perinatal management planning, resulting in a positive prognosis. This case highlights the importance of prenatal diagnosis in managing rare congenital anomalies to improve neonatal outcomes.

The Potential of Artificial Intelligence Language Models in Obstetrics: Evaluation of the Perplexity Model in Fetal Medicine

This study evaluates the use of artificial intelligence language models, specifically the Perplexity model, in obstetrics with a focus on fetal medicine. The AI’s capabilities to improve fetal diagnosis and management were explored, showing promising results in the accuracy and efficiency of medical analysis. The findings suggest an integrated future of AI in obstetric practice to optimize perinatal care.